ZM80 Monospecific Mouse Monoclonal

    Human CD123, the 70 kd IL-3 receptor α chain (IL-3Rα), is associated with the 120-140 kd β subunit. The β chain is shared with the receptors for interleukins IL-5 and GM-CSF. IL-3Rα is expressed on hematopoietic progenitors and plays an important role in hematopoietic progenitor cell growth and differentiation. This antibody has been reported to block the binding of 125I-IL-3 to high and low affinity IL-3 receptors. In functional experiments, this antibody was found to inhibit acute myeloid leukemia cell proliferation, basophil histamine release, endothelial cell-mediated IL-8 secretion, and neutrophil transmigration. At the Fifth HLDA Workshop, the human IL-3 receptor was designated CD123. This antibody reacts with plasmacytoid dendritic cells (PDC). PDC plays a crucial role in the initiation of antiviral and antitumoral immune responses and produce type I interferons a and b. CD123 antibody is useful in diagnosis of Kikuchi disease, hyaline vascular type of Castleman disease, lupus, and primary cutaneous marginal zone B-cell lymphoma.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lymph node or thymus
    Isotype:IgG2b /κ
    Immunogen:Recombinant fragment of human IL3RA protein (around aa 26-171)
    Ordering Information
    Classification IVD
    Catalogue Number Z2390ML
    Classification IVD
    Catalogue Number Z2390ML
    Package Inserts
    IFU-CD123 ZM80
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.