Preferred Clone
Formalin-Fixed, paraffin-embedded human colon carcinoma stained with anti-CD103 antibody using peroxidase-conjugate and DAB chromogen. Note the cell surface staining of subset of T cells
This MAb recognizes a protein of 150kDa, identified as CD103, which is the alpha-E integrin subunit of the heterodimeric alpha-E beta-7 (aEb7) integrin belonging to a small beta-7 integrin subfamily. CD103 is expressed on more than 95% of intraepithelial CD8+ cells and 40% of mucosa-associated T cells, whereas less than 2% of resting blood lymphocytes are CD103-positive. In several malignant conditions, such as T-cell lymphomas and hairy cell leukemia (HCL), the cells express CD103. Antibody to CD103 is an extremely useful addition to the IHC panel for diagnosing hairy cell leukemia (HCL).
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:colon
Visualization:Cell surface and cytoplasmic
Isotype:IgG
Immunogen:Recombinant human ITGAE/CD103 protein fragment (aa 775-855)
Ordering Information
Package Inserts
IFU-CD103 ZR404 - IVD 0
SDS