Gynecological Pathology
    ZR390 Rabbit Monoclonal

    The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2α) and Brg-1 (also designated SNF2β) are the ATPase subunits of the mammalian SWI/SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3), and BAF170 are thought to comprise the functional core of the SWI/SNF complex. The addition of Ini1, BAF155, and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/ SNF, including the NURF (nucleosome remodeling factor). BRG1 is mutated in multiple human tumors, including the hypercalcemic type of small cell carcinoma of the ovary and uterine sarcoma and undifferentiated carcinoma.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Normal human tissue
    Immunogen:Recombinant fragment (around aa 200-400) of human SMARCA4 protein (exact sequence is proprietary)
    Ordering Information
    Classification IVD
    Catalogue Number Z2746RL
    Classification IVD
    Catalogue Number Z2746RL
    Package Inserts
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.