preferred clone

Human lymph node stained with anti-BOB1 antibody using peroxidase-conjugate and DAB chromogen. Note nuclear and cytoplasmic staining of follicular center B cells .

BOB1

Hematopathology

ZM74 Monospecific Mouse Monoclonal

Zeta’s mouse monoclonal antibody recognizes BOB1, where expression in a variety of established B-cell lines, representing different stages of B-cell development, has suggested a constitutive, B-cell-specific expression pattern. LP cells in nodular lymphocyte predominant Hodgkin lymphoma, because they are germinal center-derived, are consistently immuno-positive for BOB1. Conversely, only some cases of classical Hodgkin lymphoma show BOB1 immuno-reactivity within the Hodgkin and Reed-Sternberg cells. Expression of BOB1 has been reported in follicular center cell lymphoma, diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL, marginal zone lymphoma, and mantle cell lymphoma may show weak to moderate immunoreactivity.

Specifications

Species Reactivity:Humans; others not tested

Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)

Supplied As:Buffer with protein carrier and preservative

Storage:Store at 2ºC to 8ºC

Control:Tonsil

Visualization:Cytoplasmic and nuclear

Isotype:IgG2b /κ

Immunogen:Recombinant human BOB1 (POU2AF1) protein fragment (around aa 148-255)

Ordering Information

USA International

Package Inserts

IFU-BOB1 ZM74

Regulatory Notice

Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.

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SDS