Human small blue round cell sarcoma stained with anti-BCOR antibody using peroxidase-conjugate and DAB chromogen. Note the nuclear staining of tumor cells.
BCL-6 interacting corepressor (BCOR) is a 1,755 amino acid protein that associates with histone deacetylases to transcriptionally repress BCL-6. BCOR mRNA is ubiquitously expressed in various tissues. However, the BCOR protein expression in adult tissue is limited to testis only. Recently, the BCOR rearrangement was detected in a subset of small blue round, spindle cell, and undifferentiated sarcomas, which results in overexpression of BCOR protein in these tumors, including small round cell sarcoma (~100%), clear cell sarcoma of kidney (100%), high-grade endometrial stromal sarcoma (100%) with YWHAE-NUTM2 translocation, and subset of synovial sarcoma (50%). The list of BCOR positive tumors is still expanding.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Endometrial stromal sarcoma
Visualization:Nuclear
Isotype:IgG1 /κ
Immunogen:A synthetic peptideagainst amino acid 1-300 mapping at the N-terminus of BCOR of human origin
Ordering Information
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