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    Soft Tissue Pathology
    C-10 Mouse Monoclonal

    BCL-6 interacting corepressor (BCOR) is a 1,755 amino acid protein that associates with histone deacetylases to transcriptionally repress BCL-6. BCOR mRNA is ubiquitously expressed in various tissues. However, the BCOR protein expression in adult tissue is limited to testis only. Recently, the BCOR rearrangement was detected in a subset of small blue round, spindle cell, and undifferentiated sarcomas, which results in overexpression of BCOR protein in these tumors, including small round cell sarcoma (~100%), clear cell sarcoma of kidney (100%), high-grade endometrial stromal sarcoma (100%) with YWHAE-NUTM2 translocation, and subset of synovial sarcoma (50%). The list of BCOR positive tumors is still expanding.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Endometrial stromal sarcoma
    Isotype:IgG1 /κ
    Immunogen:A synthetic peptideagainst amino acid 1-300 mapping at the N-terminus of BCOR of human origin
    Ordering Information
    Classification IVD
    Catalogue Number Z2334ML
    Classification IVD
    Catalogue Number Z2334ML
    Package Inserts
    IFU-BCOR C-10
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.