BCL-6

    Hematopathology
    ZM22 Monospecific Mouse Monoclonal

    Recognizes a protein of 95kDa, which is identified as Bcl-6. Antibody to bcl-6 is helpful in a number of diagnostic settings: (1) In the differential diagnosis of small B-cell lymphoma. Follicular lymphoma will show bcl-6 (and CD10) positivity whereas other small B-cell lymphomas are usually negative.(2) Bcl-6 is an important prognostic marker in diffuse large B-cell lymphomas(DLBCL), where CD10, bcl-6 and MUM1/IRF4 are used to identify germinal center and activated B-cell phenotypes.(3) Bcl-6 can be valuable in distinguishing classical Hodgkin lymphoma from nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The Reed-Sternberg cells of classical Hodgkin lymphoma are bcl-6 negative whereas the large (“L&H”) cells of NLPHL are bcl-6 positive. In contrast, anti-Bcl-6 rarely stains mantle-cell lymphoma and MALT lymphoma.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Tonsi lor diffuse large B-cell lymphoma
    Visualization:Nuclear
    Isotype:IgG1 /κ
    Immunogen:Recombinant human BCL-6 protein fragment (aa256-389) (exact sequence is proprietary)
    Ordering Information
    Classification IVD
    Catalogue Number Z2343ML
    Classification IVD
    Catalogue Number Z2343ML
    Package Inserts
    IFU-BCL-6 ZM22 - IVD
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS