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    ZR244 Rabbit Monoclonal

    ATRX is a member of the Snf2 family of helicase/ATPases, which contribute to the remodeling of the nucleosome structure in an ATP-dependent manner and facilitate the initiation of transcription and replication. Structurally, ATRX contains a PHD zinc finger motif. ATRX is regulated throughout the cell cycle, where it is differentially distributed within the nucleus. ATRX predominately associates with the nuclear matrix during interphase, while during mitosis, ATRX localizes with condensed chromatin. At the onset of the M phase, phosphorylation rapidly induces this redistribution of ATRX to the short arms of human acrocentric chromosomes. It then complexes explicitly with heterochromatin protein 1 α to mediate chromosomal segregation. Mutations in the ATRX gene correlate with a high incidence of severe X-linked form of syndromal mental retardation associated with α thalassemia or ATRX syndrome

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:High-grade glioma
    Immunogen:Recombinant fragment (around aa2200-2450) of human ATRX protein
    Ordering Information
    Classification IVD
    Catalogue Number Z2718RL
    Classification IVD
    Catalogue Number Z2718RL
    Package Inserts
    IFU-ATRX ZR244
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.