preferred clone
Formalin-fixed, paraffin-embedded human hepatic adenoma stained with anti-arginase-1 polyclonal antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic and nuclear staining of hepatocytes.
Recognizes a protein of 35-38kDa, which is identified as Arginase 1 (ARG1). Arginase is a manganese metallo-enzyme that catalyzes the hydrolysis of arginine to generate ornithine and urea. Arginase I and II are isoenzymes which differ in subcellular localization, regulation, and possibly function. Arginase I is a cytosolic enzyme, which is expressed mainly in the liver as part of the urea cycle, whereas arginase II is a mitochondrial protein found in a variety of tissues. Antibody to ARG-1 labels hepatocytes in normal tissues and granulocytes in peripheral blood. ARG-1 is a sensitive and specific marker for identification of hepatocellular carcinoma.
Specifications
Species Reactivity:Humans; others not tested
Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
Supplied As:Buffer with protein carrier and preservative
Storage:Store at 2ºC to 8ºC
Control:Liver
Visualization:Cytoplasmic
Isotype:IgG
Immunogen:Recombinant human ARG1 protein fragment (aa300-400) (Exact sequence is proprietary)
Ordering Information
Package Inserts
SDS