Urinary Pathology
    13H4 Rabbit Monoclonal

    AMACR (P504S) is an essential enzyme in the b-oxidation of branched-chain fatty acids. Recently, AMACR (P504S) was identified through cDNA library subtraction and microarrays in malignant prostate tissues. High expression of AMACR (P504S) protein is found in prostatic adenocarcinoma but not in benign prostatic tissue by immunohistochemical staining in paraffin-embedded tissues. The expression of AMACR (P504S) is also detected in two premalignant lesions of the prostate: high-grade prostatic intraepithelial neoplasia (PIN) and atypical adenomatous hyperplasia. Using AMACR (P504S) as a positive marker along with basal cell staining (34bE12 or P63) as a negative marker could help to confirm the diagnosis of small focus of prostate carcinoma on needle biopsy.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Prostate carcinoma
    Immunogen:Human AMACR (P504S) polypeptide
    Ordering Information
    Classification IVD
    Catalogue Number Z2001RL
    Classification IVD
    Catalogue Number Z2001RL
    Package Inserts
    IFU-AMACR 13H4
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.