Lung/Mediastinum Pathology
    1A4 Mouse Monoclonal

    The ALK gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumors including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumorigenesis, including ALK//EML4, ALK/RANBP2, ALK/ATIC, ALK/TFG, ALK/NPM1, ALK/SQSTM1, ALK/KIF5B, ALK/CLTC, ALK/TPM4, and ALK/MSN. The specificity of the anti-human ALK antibody (clone 1A4)was established on known ALK positive and negative non-small cell carcinoma (NSCLC). The anti-ALK presented no staining on formalin fixed ALK negative NSCLC tissue and positive staining on FFPE ALK positive NSCLC tissue using immunohistochemistry.

    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Lung adenocarcinoma with ALK translocation
    Isotype:IgG2b /κ
    Immunogen:Human recombinant protein fragment corresponding to amino acids 1300-1620 of human ALK produced in E.coli
    Ordering Information
    Classification IVD
    Catalogue Number Z2289ML
    Classification IVD
    Catalogue Number Z2289ML
    Package Inserts
    IFU-ALK 1A4
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.