ALK-1

    Lung/Mediastinum Pathology
    ZR305 Rabbit Monoclonal

    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase of the insulin receptor superfamily. ALK-1 is typically expressed at low levels in regions of the developing central and peripheral nervous system. ALK-1 may be activated in cancer through multiple mechanisms. The most common mechanism is through the formation of a fusion protein from chromosomal translocations, as in the case of anaplastic large cell lymphoma (ALCL) and inflammatory myofibroblastic tumors. ALK-1 may also be amplified through mutation, as in neuroblastomas. Various solid tumors, such as non-small cell lung carcinoma (NSCLC) and brain cancers were also found to aberrantly express ALK-1. ALK-1 staining is present within both the nucleus and cytoplasm and is positive in about 60% of ALCL. ALK-1 protein expression by tumor cells is an independent prognostic factor that predicts a favorable outcome.

    Specifications
    Species Reactivity:Humans; others not tested
    Known Applications:Immunohistochemistry (formalin-fixed, paraffin-embedded tissues)
    Supplied As:Buffer with protein carrier and preservative
    Storage:Store at 2ºC to 8ºC
    Control:Anaplastic large cell lymphoma or Lung adenocarcinoma with ALK translocation
    Visualization:Cytoplasmic and nuclear
    Isotype:IgG
    Immunogen:Human ALK-1 protein fragment around aa 1058-1620
    Ordering Information
    Classification IVD
    Catalogue Number Z2534RL
    Classification IVD
    Catalogue Number Z2534RL
    Package Inserts
    IFU-ALK-1 (ZR305)
    Regulatory Notice
    Product classification varies based on regulations of individual countries. Please contact your local distributor for more information. Products labeled as ASR or RUO in the US might be available as IVD or RUO in respective countries.
    SDS
    SDS